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question:Summarize what this article says about depression for a layman.Major depression is one of the most prevalent and debilitating psychiatric afflictions. It is characterized by pervasive and recurrent episodes of low mood and motivation, despair and anhedonia. Despite the availability of several classes of antidepressants, more than a third of patients are either unremitting or relapsing (Bambico and Gobbi, 2008, Zisook et al., 2008). Antidepressants that are known to act on the brain's monoamine systems are limited by a delayed onset of therapeutic action. Moreover, the pathophysiology of depression is far from being fully elucidated. Multiple levels of dysfunction have been proposed, including impaired synaptic transmission of the monoamine 5-hydroxytryptamine (5-HT or serotonin) (Bambico et al., 2009a), which is produced by the midbrain raphe 5-HT neurons (Dahlström and Fuxe, 1964, Descarries et al., 1982), and known to regulate emotional, vegetative and neuroendocrine functions (Holmes, 2008). Not surprisingly, drugs that augment 5-HT transmission, such as selective serotonin reuptake inhibitors (SSRIs), are most preferred first-line treatments (Vaswani et al., 2003). Their chronic application facilitates exocytosis of 5-HT and/or increases 5-HT synaptic availability in corticolimbic regions extensively innervated by the raphe. Many of these forebrain structures, including the prefrontal cortex, hippocampus and amygdala are implicated in mood regulation and stress adaptation (Holmes, 2008). On the other hand, chronic stress that is known to be a risk factor for depression impairs presynaptic and postsynaptic 5-HT transmission (Bambico et al., 2009b). Also, acute or repeated 5-HT or tryptophan depletion precipitates anxiety/depression-like behaviors in animals (Blokland et al., 2002) and mood-lowering effects in humans (for review, Young and Leyton, 2002), exacerbates anxiogenic responses in human subjects (Miller et al., 2000), and triggers relapse in depressive patients (for review, Van der Does, 2001).
answer:Major depression, characterized by low mood and motivation, despair, and lack of pleasure, is one of the most common mental health disorders. Even though several drugs exist to treat it, more than a third of people who have it don't get relief. However, depression isn't fully understood. The go-to treatment is selective serotonin reuptake inhibitors, or SSRI drugs. Parts of the front of the brain regulate mood and response to stress, but chronic stress can impair the brain. A lack of tryptophan - an amino acid - can also trigger depression.
question:Create a couple of paragraphs of about 150-200 words talking about walruses and walrus facts for a kindergarten class?
answer:Have you guys ever seen a walrus before? No? Here’s a picture of one. Walruses are mammals. And you can see that they have very long tusks, which look like teeth but are actually used to break holes in the ice so they can breathe! Walruses also use their tusks to help haul themselves out of the water onto the ice and even to fight other walruses! So where do you think walruses live? That’s right, in and around the ice. In fact, walruses migrate, which means they move with ice floes. But walruses never move too far away from land because that’s where their food lives. They eat mollusks and other animals that don’t have backbones. They can go deep into the icy water to eat. Some walruses go as deep as 20-30 meters, which is 100 feet, or almost 20 adults long! In the Arctic, people have always used walrus meat to eat, and they carve the tusks to make art and trade them with other people.
question:Write a short free verse poem about art.
answer:How happy is the imaginative artist?Down, down, down into the darkness,Gently it goes - the creative, the unique, the original.Pay attention to the art; to the paint colors.Paintings are non-classical. The paintings are non-modern.I saw the visual communication of my generation being born,How I embraced the change from paint to pixels. I watched the painting artist mourn. The graphics faded and jaundiced,Click Click Click.
question:What major league teams did Ozzie Smith play for during his career?
answer:Ozzie Smith (Osborne Earl Smith) played for the San Diego Padres from 1978 until 1981. He played for the St. Louis Cardinals from 1982 until 1996.
question:Pretend you are a food truck operator specializing in Lovecraftian monster cuisine. Create an ad read for a podcast incentivizing people to follow you on foot truck apps. Your name is Milles Gotham and your food truck restaurant is the Necr-OM-NOM-icon. Include some of your menu items.
answer:Hotdogs, grilled cheese, kabobs, taco fusion; No matter where you go, it seems like every food truck has such similar bland options. Not anymore! Introducing Necr-OM-NOM-icon: the freshest food truck on the block. We have all the greatest hits with twists and ingredients you've never heard of. Our flavors are sure to take you to another transcended realm of consciousness and have you questioning your reality when you're finished. You'd be absolutely mad to not come back for more! Try some of our selections using only the best ingredients: The King Cake in Yellow, Tentacle Churros, Yigdogs, or even Mi-Go soup! Summon us to your city today, or find us on any of your favorite food truck tracking apps. Look for a tear in reality; we'll be there to serve you.
question:Write a romantic meet-cute between Samantha and Aiden. Aiden is a handsome young man with green eyes and dyed red hair and Samantha is taken aback when he offers to talk to her when she shows how scared she is of flights. The word count should be exactly 240 words.
answer:Samantha took a deep breath in and held it. Her heart was jackhammering against her ribs so hard it hurt. She wasn’t scared of flying - or at least, she hadn’t been growing up. At that moment though, Samantha was sure she’d die of fright.She felt a presence and turned her head to the side to see a red-haired stranger put his carry-on in the compartment. He settled into the seat beside her once he was done and gave her a nod of acknowledgment. Sakura nodded back, taken aback by his appearance. He was handsome, sort of. With sharp, green eyes lined with dark bruises attributed to a possible case of insomnia. His mouth was set in a neutral, blank line. His hair was an unnatural red, like a fire truck, but it was dyed very well. The air stewardess passed by, making sure they were comfortable and checking that the compartments were closed properly. Samantha concentrated on calming her heart, and on fighting back the negative thoughts that threatened to engulf her.“Scared of flying?” a voice rasped.She looked at her companion, surprised to hear him talk.“A little,” she admitted. “First time?”“No, I’ve flown before.”“If you need a distraction, I’m happy to talk with you.”Samantha considered him for a moment. He smiled, and her mind was made up.“My name is Samantha.”“Aiden,” he said, smiling wider.